Correction of thiazide hyperuricemia by potassium chloride and ammonium chloride.

Large doses of KCI lowered serum uric acid while producing mild, apparently unrelated, uricosuria in four chlorothiazide-treated subjects. In two control subjects KCI also caused mild uricosuria, but had a negligible effect on serum uric acid concentration. Ammonium chloride decreased serum urate in all six subjects, while urinary uric acid excretion remained essentially unchanged. It is suggested that these changes in serum uric acid are secondary to redistribution of urate among body compartments. Grande doses de KCI reduceva le concentrationes seral de acido uric e produceva leve grados de apparentemente non relationate uricosuria in quatro subjectos sub tractamento a chlorothiazida. In duo subjectos de controlo, KCI causava similemente leve grados de uricosuria sed exerceva non plus que un negligible effecto super le nivellos seral de acido uric. Chloruro de ammonium reduceva le urato seral in omne casos in un serie de 6 subjectos durante que le excretion urinari de acido uric remaneva essentialmente inalterate. Es postulate que iste alterationes in le nivello seral de acido uric es un effecto secundari del redistribution de urato in le diverse compartimentos corporee.